Vaccine Innovation. Beyond Convention.
We are dedicated to eliminating bacterial infections such as invasive pneumococcal disease, Group A Strep and Shigella to protect every child born and every adult at risk across the globe.
Pushing the Boundaries of What’s Possible
Despite current efforts, Streptococcus pneumoniae bacteria continues to cause significant global morbidity and mortality, particularly for young children and older adults. This underscores the importance of advancing our potentially best-in-class pneumococcal conjugate vaccines (PCVs), including VAX-31, a 31-valent PCV, and VAX-24, a 24-valent PCV, being studied for the prevention of invasive pneumococcal disease (IPD).
Re-Engineering How Vaccines are Made
We strive to overcome the limitations of conventional, cell-based vaccine approaches using advanced chemistry and modern synthetic techniques – including our cell-free protein synthesis platform – to produce broad-spectrum vaccines that are uniquely capable of breaking down bacteria’s complex defense mechanisms while preserving robust immunogenicity.
Building a Pipeline of High-Fidelity and Broad-Spectrum Vaccines
Our PCV franchise, comprising VAX-31 and VAX-24, has the potential to improve upon existing pneumococcal vaccines, setting a new standard-of-care and raising the bar for immunogenicity. Our site-specific, carrier-sparing platform has the potential to deliver the broadest-spectrum PCVs that provide protection against both currently circulating and historically prevalent serotypes. Additional candidates in early-stage development target Group A Strep and Shigella.
Latest News
Positive VAX-31 Phase 1/2 Adult Data Published in The Lancet Infectious Diseases Highlight Best-in-Class Potential of Vaxcyte’s 31-Valent Pneumococcal Conjugate Vaccine (PCV) Candidate
Vaxcyte Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Business Update
Vaxcyte Doses First Participants in OPUS-3 Phase 3 Trial Evaluating VAX-31 in Adults Previously Vaccinated with Lower-Valency Pneumococcal Vaccines
Careers: Built to Scale with Purpose
Looking for higher aspirations to ignite your mind and inspire your heart? Join a team that brings grit and grace to our mission of protecting humankind from the consequences of bacterial infections.
