Vaccine Innovation. Beyond Convention.

We are dedicated to eliminating bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella to protect every child born and every adult at risk across the globe.

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Pushing the Boundaries of What’s Possible

Despite widespread vaccination with current pneumococcal conjugate vaccines (PCVs), there is an abundance of non-vaccine strains of the Streptococcus pneumoniae bacteria causing significant morbidity and mortality. This underscores the importance of advancing VAX-24, our lead 24-valent PCV candidate, which is the broadest-spectrum PCV in the clinic today. Upon achieving clinical proof-of-concept, VAX-24 was granted FDA Breakthrough Therapy designation for the prevention of invasive pneumococcal disease in adults.

Re-Engineering How Vaccines are Made

We strive to overcome the limitations of conventional, cell-based vaccine approaches using advanced chemistry and modern synthetic techniques – including our XpressCF™ cell-free protein synthesis platform – to produce broad-spectrum vaccines that are uniquely capable of breaking down bacteria’s complex defense mechanisms while preserving immunogenicity.

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Building a Pipeline of High-Fidelity and Broad-Spectrum Vaccines

Our PCV franchise is intended to improve upon existing pneumococcal vaccines by covering a significant portion of the invasive pneumococcal disease currently in circulation that is associated with high case-fatality rates, antibiotic resistance and meningitis. Following VAX-24, we are developing VAX-31, a 31-valent PCV candidate. Additional vaccine candidates in preclinical development target Group A Strep, periodontitis and Shigella.

Latest News


Vaxcyte to Present at the 2023 Cantor Fitzgerald Global Healthcare Conference

SAN CARLOS, Calif., Sept. 19, 2023 (GLOBE NEWSWIRE) -- Vaxcyte, Inc. (Nasdaq: PCVX), a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, today announced that Company management will participate in a

Vaxcyte Reports Second Quarter 2023 Financial Results and Provides Business Update

-- Advanced Ongoing VAX-24 Phase 2 Infant Study to Second Stage, Dosing First New Participants in July 2023; Topline Data from Primary Immunization Series Expected by 2025 -- -- Completed Phase 2 VAX-24 Adult Program for the Prevention of Invasive Pneumococcal Disease (IPD); Topline Phase 3 Data

Vaxcyte Advances to Second Stage of Ongoing Phase 2 Study Evaluating VAX-24 for the Prevention of Invasive Pneumococcal Disease in Infants

-- Initiation of Stage 2 Approved by Independent Data Safety Monitoring Board Following Review of Stage 1 Safety and Tolerability Data -- -- The Stage 2 Portion of VAX-24 Infant Study Will Include Prevnar 20 ® (PCV20) as Study Comparator -- -- Company Expects to Announce Topline Data from Primary

Careers: Built to Scale with Purpose

Looking for higher aspirations to ignite your mind and inspire your heart? Then join a team that brings grit and grace to the challenge of protecting every human from the consequences of endemic bacterial infections.